Check-out from hotel. Take train from Milan station to Venice Mestre station.
Arrival at Venice Mestre station. Make your own way to hotel.
Check-in at hotel. Overnight stay.
Breakfast at hotel.
Check-out from hotel. Take train from Florence station to Rome.
Arrival at Rome Station. Drop luggage at Rome hotel and proceed to visit Vatican Museum and Sistine Chapel. Standard Ticket for Vatican Museum.
Later proceed to hotel. Check-in at hotel. Overnight stay.